Short Summary/Abstract:

Accumulating and converging evidence suggests that hippocampal subfield neuropathology might be an important factor underlying psychosis risk, disease progression, and symptomology. The hippocampus is a highly-connected “hub” brain region which is particularly vulnerable to dysfunction. Hippocampal structural volume loss has been consistently demonstrated within psychosis disease phases, and some studies have linked this to symptom severity and memory dysfunction. The hippocampus comprises various anatomically and functionally distinct subfields, including the dentate gyrus, Cornu Ammonis (CA) regions of the hippocampus proper, and the subiculum. However, information around how hippocampal subfield volume changes evolve across disease phases is currently lacking.  Using the rich data available in PsyShareD, we will explore the trajectory and spatial distribution of subregional atrophy across disease phases. Also, we will determine how volume loss in each subfield links (1) to symptomology, and (2) learning/memory recall performance.