Cellular Stress: Comorbid multi-organ Aging in PsychosEs (C-SCAPE)

Short Summary/Abstract:

To assess psychosis as a multisystem disorder of accelerated aging, driven by inflammation and cellular stress. Using PsyShareD date, we will explore one of the core biomarkers of psychosis as a reduction in grey matter volume (GMV), cortical thinning and increasingly established evidence of advancing brain age in schizophrenia. BrainAge models demonstrate at least a 5-year gap between chronological age and predicted brain age compared to normative data, with reduced GMV focused in orbito-frontal and limbic areas. We will validate aging models across organs and systems in new well characterised psychosis cohort, with in-depth exploration of mechanisms and treatment targets.

Investigators & Affiliations:

  • Prof. Rachel Upthegrove, Department of Psychiatry, University of Oxford 
  • Dr Amalie Couch, Department of Psychiatry, University of Oxford 
  • Dr Benjamin Perry, Institute for Mental Health, University of Birmingham 
  • Dr Jack Rogers, Institute for Mental Health, University of Birmingham 
  • Dr Paris Lalousis, Institute of Psychiatry, Psychology & Neuroscience, Kings College London 
  • Dr Toby Pilinger, Institute of Psychiatry, Psychology & Neuroscience, Kings College London 
  • Dr Zachery Freyberg, University of Pittsburgh Department of Psychiatry 
  • Dr Lahiru Handunnetti, Department of Psychiatry, University of Oxford