PSYD_13_2025: Cellular Stress: Comorbid multi-organ Aging in PsychosEs (C-SCAPE)

Short Summary/Abstract:

To assess psychosis as a multisystem disorder of accelerated aging, driven by inflammation and cellular stress. Using PsyShareD date, we will explore one of the core biomarkers of psychosis as a reduction in grey matter volume (GMV), cortical thinning and increasingly established evidence of advancing brain age in schizophrenia. BrainAge models demonstrate at least a 5-year gap between chronological age and predicted brain age compared to normative data, with reduced GMV focused in orbito-frontal and limbic areas. We will validate aging models across organs and systems in new well characterised psychosis cohort, with in-depth exploration of mechanisms and treatment targets.

Investigators & Affiliations:

  • University of Oxford – Department of Psychiatry
    • → Prof. Rachel Upthegrove
    • → Dr Amalie Couch
    • → Dr Lahiru Handunnetti
  • University of Birmingham – Institute for Mental Health
    • → Dr Benjamin Perry
    • → Dr Jack Rogers
  • King’s College London – Institute of Psychiatry, Psychology & Neuroscience
    • → Dr Paris Lalousis
    • → Dr Toby Pilinger
  • University of Pittsburgh – Department of Psychiatry
    • → Dr Zachery Freyberg

Datasets Approved:

PSYD_0101 - PSYD_0123; PSYD_0301 - PSYD_0302; PSYD_0401 - PSYD_0403; PSYD_0601 - PSYD_0605; PSYD_0701; PSYD_0801 - PSYD_0803; PSYD_1101; PSYD_1601; PSYD_1801; PSYD_1901; PSYD_2101; PSYD_2201; PSYD_2401; PSYD_2501; PSYD_2601; PSYD_2801; PSYD_3001; PSYD_3101; PSYD_3401